2Y63

Crystal structure of Leishmanial E65Q-TIM complexed with Bromohydroxyacetone phosphate

Summary for 2Y63

Entry DOI	10.2210/pdb2y63/pdb
Related	1AMK 1IF2 1N55 1QDS 2VXN 2Y61 2Y62
Descriptor	TRIOSEPHOSPHATE ISOMERASE, (3-bromo-2-oxo-propoxy)phosphonic acid (3 entities in total)
Functional Keywords	isomerase, fatty acid biosynthesis, transition state analogue, glycolysis, pentose shunt, gluconeogenesis, tim, gop, glycosome, lipid synthesis, transition state
Biological source	LEISHMANIA MEXICANA
Cellular location	Cytoplasm: P48499
Total number of polymer chains	1
Total formula weight	27441.19
Authors	Venkatesan, R.,Alahuhta, M.,Pihko, P.M.,Wierenga, R.K. (deposition date: 2011-01-19, release date: 2011-12-14, Last modification date: 2023-12-20)
Primary citation	Venkatesan, R.,Alahuhta, M.,Pihko, P.M.,Wierenga, R.K. High Resolution Crystal Structures of Triosephosphate Isomerase Complexed with its Suicide Inhibitors: The Conformational Flexibility of the Catalytic Glutamate in its Closed, Liganded Active Site. Protein Sci., 20:1387-, 2011 Cited by PubMed: 21633986 DOI: 10.1002/PRO.667 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.97 Å)

Structure validation