2Y0I
FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH TANKYRASE-2 (TNKS2) FRAGMENT PEPTIDE (21-MER)
Summary for 2Y0I
Entry DOI | 10.2210/pdb2y0i/pdb |
Related | 1H2K 1H2L 1H2M 1H2N 1IZ3 1MZE 1MZF 1YCI 2CGN 2CGO 2W0X 2WA3 2WA4 2XUM |
Descriptor | HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR, TANKYRASE-2, FE (II) ION, ... (7 entities in total) |
Functional Keywords | oxidoreductase-peptide complex, dioxygenase, helix-loop-helix-beta, facial triad, asparaginyl/aspartyl hydroxylase, ankyrin repeat domain, oxidoreductase/peptide |
Biological source | HOMO SAPIENS (HUMAN) More |
Cellular location | Nucleus: Q9NWT6 Cytoplasm: Q9H2K2 |
Total number of polymer chains | 2 |
Total formula weight | 43611.50 |
Authors | Chowdhury, R.,McDonough, M.A.,Schofield, C.J. (deposition date: 2010-12-02, release date: 2011-02-02, Last modification date: 2023-12-20) |
Primary citation | Yang, M.,Chowdhury, R.,Ge, W.,Hamed, R.B.,McDonough, M.A.,Claridge, T.D.,Kessler, B.M.,Cockman, M.E.,Ratcliffe, P.J.,Schofield, C.J. Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains. FEBS J., 278:1086-1097, 2011 Cited by PubMed: 21251231DOI: 10.1111/j.1742-4658.2011.08022.x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.28 Å) |
Structure validation
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