2XUM

FACTOR INHIBITING HIF (FIH) Q239H MUTANT IN COMPLEX WITH ZN(II), NOG AND ASP-SUBSTRATE PEPTIDE (20-MER)

Summary for 2XUM

Entry DOI	10.2210/pdb2xum/pdb
Related	1H2K 1H2L 1H2M 1H2N 1IZ3 1MZE 1MZF 1YCI 2CGN 2CGO 2W0X 2WA3 2WA4
Descriptor	HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR, ASP-SUBSTRATE PEPTIDE 2, ZINC ION, ... (6 entities in total)
Functional Keywords	oxidoreductase-peptide complex, non-heme, dioxygenase, oxygenase, hypoxia, metal-binding, helix-loop-helix-beta, facial triad signaling, beta-hydroxylation, transcription activator/inhibitor, oxidoreductase/peptide
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	43072.50
Authors	Chowdhury, R.,McDonough, M.A.,Schofield, C.J. (deposition date: 2010-10-19, release date: 2010-12-22, Last modification date: 2023-12-20)
Primary citation	Yang, M.,Ge, W.,Chowdhury, R.,Claridge, T.D.,Kramer, H.B.,Schmierer, B.,McDonough, M.A.,Gong, L.,Kessler, B.M.,Ratcliffe, P.J.,Coleman, M.L.,Schofield, C.J. Asparagine and aspartate hydroxylation of the cytoskeletal ankyrin family is catalyzed by factor-inhibiting hypoxia-inducible factor. J. Biol. Chem., 286:7648-7660, 2011 Cited by PubMed: 21177872 DOI: 10.1074/jbc.M110.193540 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation