2XUM
FACTOR INHIBITING HIF (FIH) Q239H MUTANT IN COMPLEX WITH ZN(II), NOG AND ASP-SUBSTRATE PEPTIDE (20-MER)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR | polymer | 349 | 40338.3 | 1 | UniProt (Q9NWT6) Pfam (PF13621) | Homo sapiens (Human) | FACTOR INHIBITING HIF-1, FIH-1, HYPOXIA-INDUCIBLE FACTOR ASPARAGINE HYDROXYLASE |
| 2 | B (S) | ASP-SUBSTRATE PEPTIDE 2 | polymer | 20 | 2233.5 | 1 | SYNTHETIC CONSTRUCT | ||
| 3 | C (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | D (A) | N-OXALYLGLYCINE | non-polymer | 147.1 | 1 | Chemie (OGA) | |||
| 5 | E, F, G (A) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 6 | H, I (A, S) | water | water | 18.0 | 154 | Chemie (HOH) |
Sequence modifications
A: 1 - 349 (UniProt: Q9NWT6)
| PDB | External Database | Details |
|---|---|---|
| His 239 | Gln 239 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 42571.8 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 500.7 | |
| All* | Total formula weight | 43072.5 |
