2XCK
Crystal structure of PDK1 in complex with a pyrazoloquinazoline inhibitor
Summary for 2XCK
Entry DOI | 10.2210/pdb2xck/pdb |
Related | 1H1W 1OKY 1OKZ 1UU3 1UU7 1UU8 1UU9 1UVR 1W1D 1W1G 1W1H 1Z5M 2BIY 2VKI 2XCH |
Descriptor | 3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1, 1-METHYL-8-{[4-(4-METHYLPIPERAZIN-1-YL)PHENYL]AMINO}-N-[(2-METHYLPYRIDIN-4-YL)METHYL]-4,5-DIHYDRO-1H-PYRAZOLO[4,3-H]QUINAZOLINE-3-CARBOXAMIDE, GLYCEROL, ... (5 entities in total) |
Functional Keywords | pi3-kinase signalling, transferase, atp-binding, serine/threonine-protein kinase |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cytoplasm: O15530 |
Total number of polymer chains | 1 |
Total formula weight | 36609.78 |
Authors | Angiolini, M.,Banfi, P.,Casale, E.,Casuscelli, F.,Fiorelli, C.,Saccardo, M.B.,Silvagni, M.,Zuccotto, F. (deposition date: 2010-04-23, release date: 2010-07-28, Last modification date: 2023-12-20) |
Primary citation | Angiolini, M.,Banfi, P.,Casale, E.,Casuscelli, F.,Fiorelli, C.,Saccardo, M.B.,Silvagni, M.,Zuccotto, F. Structure-Based Optimization of Potent Pdk1 Inhibitors. Bioorg.Med.Chem.Lett., 20:4095-, 2010 Cited by PubMed: 20621725DOI: 10.1016/J.BMCL.2010.05.070 PDB entries with the same primary citation |
Experimental method |
Structure validation
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