2XCK
Crystal structure of PDK1 in complex with a pyrazoloquinazoline inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | 3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1 | polymer | 309 | 35429.6 | 1 | UniProt (O15530) Pfam (PF00069) In PDB | HOMO SAPIENS (HUMAN) | HPDK1 |
| 2 | A | 1-METHYL-8-{[4-(4-METHYLPIPERAZIN-1-YL)PHENYL]AMINO}-N-[(2-METHYLPYRIDIN-4-YL)METHYL]-4,5-DIHYDRO-1H-PYRAZOLO[4,3-H]QUINAZOLINE-3-CARBOXAMIDE | non-polymer | 523.6 | 1 | Chemie (MH4) | |||
| 3 | A | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 4 | A | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 5 | water | water | 18.0 | 139 | Chemie (HOH) |
Sequence modifications
A: 51 - 359 (UniProt: O15530)
| PDB | External Database | Details |
|---|---|---|
| Thr 96 | Val 46 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35429.6 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1180.2 | |
| All* | Total formula weight | 36609.8 |
