2XAG

Crystal structure of LSD1-CoREST in complex with para-bromo-(-)-trans- 2-phenylcyclopropyl-1-amine

2XAG の概要

• エントリーDOI: 10.2210/pdb2xag/pdb
• 関連するPDBエントリー: 2COM 2H94 2IW5 2UXN 2UXX 2V1D 2X0L 2XAF 2XAH 2XAJ 2XAQ 2XAS
• 分子名称: LYSINE-SPECIFIC HISTONE DEMETHYLASE 1, REST COREPRESSOR 1, FLAVIN-ADENINE DINUCLEOTIDE, ... (4 entities in total)
• 機能のキーワード: amine oxidase, chromatin regulator, histone inhibitor binding, methylation, nucleosome core, oxidoreductase, oxidoreductase-repressor complex, chromatin remodelling, transcription
• 由来する生物種: HOMO SAPIENS; 詳細
• 細胞内の位置: Nucleus: O60341 Q9UKL0
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 147127.05

構造登録者

Binda, C.,Valente, S.,Romanenghi, M.,Pilotto, S.,Cirilli, R.,Karytinos, A.,Ciossani, G.,Botrugno, O.A.,Forneris, F.,Tardugno, M.,Edmondson, D.E.,Minucci, S.,Mattevi, A.,Mai, A. (登録日: 2010-03-31, 公開日: 2010-05-05, 最終更新日: 2011-10-12)

• 主引用文献: Binda, C.,Valente, S.,Romanenghi, M.,Pilotto, S.,Cirilli, R.,Karytinos, A.,Ciossani, G.,Botrugno, O.A.,Forneris, F.,Tardugno, M.,Edmondson, D.E.,Minucci, S.,Mattevi, A.,Mai, A.; Biochemical, Structural, and Biological Evaluation of Tranylcypromine Derivatives as Inhibitors of Histone Demethylases Lsd1 and Lsd2.; J.Am.Chem.Soc., 132:6827-, 2010; PubMed: 20415477; DOI: 10.1021/JA101557K

実験手法

X-RAY DIFFRACTION (3.1 Å)