2XAE

Crystal structure of human kinesin Eg5 in complex with (R)-2-amino-3-((S)-2-methyl-1,1-diphenylbutylthio)propanoic acid

Summary for 2XAE

Related1II6 2X7E 2FKY 2UYI 2X7C 1Q0B 2WOG 2X2R 2G1Q 2UYM 1YRS 2FL6 2GM1 1X88 2X7D 2FL2
DescriptorKINESIN-LIKE PROTEIN KIF11, (2R)-2-AMINO-3-[(4-CHLOROPHENYL)-DIPHENYL-METHYL]SULFANYL-PROPANOIC ACID, MAGNESIUM ION, ... (7 entities in total)
Functional Keywordscell cycle, mitosis, ksp
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationCytoplasm P52732
Total number of polymer chains3
Total molecular weight126038.66
Authors
Kaan, H.Y.K.,Weiss, J.,Menger, D.,Ulaganathan, V.,Tkocz, K.,Laggner, C.,Popowycz, F.,Joseph, B.,Kozielski, F. (deposition date: 2010-03-31, release date: 2011-03-30, Last modification date: 2011-07-13)
Primary citation
Kaan, H.Y.K.,Weiss, J.,Menger, D.,Ulaganathan, V.,Tkocz, K.,Laggner, C.,Popowycz, F.,Joseph, B.,Kozielski, F.
Structure-Activity Relationship and Multidrug Resistance Study of New S-Trityl-L-Cysteine Derivatives as Inhibitors of Eg5.
J.Med.Chem., 54:1576-, 2011
PubMed: 21344920 (PDB entries with the same primary citation)
DOI: 10.1021/JM100991M
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.6 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.249100.8%7.2%3.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution