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2XAE

Crystal structure of human kinesin Eg5 in complex with (R)-2-amino-3-((S)-2-methyl-1,1-diphenylbutylthio)propanoic acid

Summary for 2XAE
Entry DOI10.2210/pdb2xae/pdb
Related1II6 1Q0B 1X88 1YRS 2FKY 2FL2 2FL6 2G1Q 2GM1 2UYI 2UYM 2WOG 2X2R 2X7C 2X7D 2X7E
DescriptorKINESIN-LIKE PROTEIN KIF11, (2R)-2-AMINO-3-[(4-CHLOROPHENYL)-DIPHENYL-METHYL]SULFANYL-PROPANOIC ACID, MAGNESIUM ION, ... (7 entities in total)
Functional Keywordscell cycle, mitosis, ksp
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationCytoplasm: P52732
Total number of polymer chains3
Total formula weight126038.66
Authors
Kaan, H.Y.K.,Weiss, J.,Menger, D.,Ulaganathan, V.,Tkocz, K.,Laggner, C.,Popowycz, F.,Joseph, B.,Kozielski, F. (deposition date: 2010-03-31, release date: 2011-03-30, Last modification date: 2023-12-20)
Primary citationKaan, H.Y.K.,Weiss, J.,Menger, D.,Ulaganathan, V.,Tkocz, K.,Laggner, C.,Popowycz, F.,Joseph, B.,Kozielski, F.
Structure-Activity Relationship and Multidrug Resistance Study of New S-Trityl-L-Cysteine Derivatives as Inhibitors of Eg5.
J.Med.Chem., 54:1576-, 2011
Cited by
PubMed: 21344920
DOI: 10.1021/JM100991M
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.6 Å)
Structure validation

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