2XAE
Crystal structure of human kinesin Eg5 in complex with (R)-2-amino-3-((S)-2-methyl-1,1-diphenylbutylthio)propanoic acid
Summary for 2XAE
Entry DOI | 10.2210/pdb2xae/pdb |
Related | 1II6 1Q0B 1X88 1YRS 2FKY 2FL2 2FL6 2G1Q 2GM1 2UYI 2UYM 2WOG 2X2R 2X7C 2X7D 2X7E |
Descriptor | KINESIN-LIKE PROTEIN KIF11, (2R)-2-AMINO-3-[(4-CHLOROPHENYL)-DIPHENYL-METHYL]SULFANYL-PROPANOIC ACID, MAGNESIUM ION, ... (7 entities in total) |
Functional Keywords | cell cycle, mitosis, ksp |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cytoplasm: P52732 |
Total number of polymer chains | 3 |
Total formula weight | 126038.66 |
Authors | Kaan, H.Y.K.,Weiss, J.,Menger, D.,Ulaganathan, V.,Tkocz, K.,Laggner, C.,Popowycz, F.,Joseph, B.,Kozielski, F. (deposition date: 2010-03-31, release date: 2011-03-30, Last modification date: 2023-12-20) |
Primary citation | Kaan, H.Y.K.,Weiss, J.,Menger, D.,Ulaganathan, V.,Tkocz, K.,Laggner, C.,Popowycz, F.,Joseph, B.,Kozielski, F. Structure-Activity Relationship and Multidrug Resistance Study of New S-Trityl-L-Cysteine Derivatives as Inhibitors of Eg5. J.Med.Chem., 54:1576-, 2011 Cited by PubMed: 21344920DOI: 10.1021/JM100991M PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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