2XAE

Crystal structure of human kinesin Eg5 in complex with (R)-2-amino-3-((S)-2-methyl-1,1-diphenylbutylthio)propanoic acid

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003777	molecular_function	microtubule motor activity
A	0005524	molecular_function	ATP binding
A	0007018	biological_process	microtubule-based movement
A	0008017	molecular_function	microtubule binding
B	0003777	molecular_function	microtubule motor activity
B	0005524	molecular_function	ATP binding
B	0007018	biological_process	microtubule-based movement
B	0008017	molecular_function	microtubule binding
C	0003777	molecular_function	microtubule motor activity
C	0005524	molecular_function	ATP binding
C	0007018	biological_process	microtubule-based movement
C	0008017	molecular_function	microtubule binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 2XA A 1365

Chain	Residue
A	GLU116
A	ARG221
A	HOH2121
A	GLY117
A	GLU118
A	ARG119
A	ALA133
A	PRO137
A	TYR211
A	LEU214
A	GLU215

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 1366

Chain	Residue
A	THR112
A	ADP1367
A	HOH2037
A	HOH2038
A	HOH2124
A	HOH2126

---

site_id	AC3
Number of Residues	19
Details	BINDING SITE FOR RESIDUE ADP A 1367

Chain	Residue
A	ARG24
A	ARG26
A	PRO27
A	GLN106
A	GLY108
A	THR109
A	GLY110
A	LYS111
A	THR112
A	PHE113
A	GLU118
A	MG1366
A	HOH2037
A	HOH2122
A	HOH2123
A	HOH2124
A	HOH2126
A	HOH2128
A	HOH2129

---

site_id	AC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE 2XA B 1365

Chain	Residue
B	GLU116
B	GLY117
B	GLU118
B	TRP127
B	PRO137
B	TYR211
B	LEU214
B	ARG221
B	HOH2150

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG B 1366

Chain	Residue
B	THR112
B	ADP1367
B	HOH2052
B	HOH2111
B	HOH2153
B	HOH2155

---

site_id	AC6
Number of Residues	17
Details	BINDING SITE FOR RESIDUE ADP B 1367

Chain	Residue
B	ARG24
B	ARG26
B	PRO27
B	GLY108
B	THR109
B	GLY110
B	LYS111
B	THR112
B	PHE113
B	GLU118
B	MG1366
B	HOH2002
B	HOH2052
B	HOH2151
B	HOH2153
B	HOH2154
B	HOH2155

---

site_id	AC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE 2XA C 1364

Chain	Residue
C	THR112
C	GLU116
C	GLY117
C	GLU118
C	ARG119
C	TYR211
C	LEU214
C	GLU215

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG C 1365

Chain	Residue
C	THR112
C	ADP1366
C	HOH2023
C	HOH2048
C	HOH2080
C	HOH2081

---

site_id	AC9
Number of Residues	18
Details	BINDING SITE FOR RESIDUE ADP C 1366

Chain	Residue
C	HOH2081
C	ARG24
C	ARG26
C	PRO27
C	GLN106
C	GLY108
C	THR109
C	GLY110
C	LYS111
C	THR112
C	PHE113
C	GLU118
C	MG1365
C	HOH2023
C	HOH2077
C	HOH2078
C	HOH2079
C	HOH2080

---

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 1368

Chain	Residue
B	MET184
B	PHE185
B	ASP186
B	ARG312
B	ARG318

---

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 C 1367

Chain	Residue
C	MET184
C	PHE185
C	ASP186
C	ARG312
C	ARG318

---

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 1369

Chain	Residue
B	GLU42
B	CYS43
B	ALA74
B	HOH2156

---

site_id	BC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 1368

Chain	Residue
A	LEU30
A	HOH2128

---

Functional Information from PROSITE/UniProt

site_id	PS00411
Number of Residues	12
Details	KINESIN_MOTOR_1 Kinesin motor domain signature. GKLnLVDLAGSE

Chain	Residue	Details
A	GLY259-GLU270

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00283

Chain	Residue	Details
A	GLY105
B	GLY105
C	GLY105

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	LYS146
B	LYS146
C	LYS146

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