2X6E

Aurora-A bound to an inhibitor

2X6E の概要

関連するPDBエントリー1MUO 2X6D 2J50 2W1D 1OL6 2BMC 2C6E 2J4Z 1OL5 2C6D 2WTW 2WQE 2W1C 2W1G 2WTV 1OL7 2W1E 2W1F 1MQ4
分子名称SERINE/THREONINE-PROTEIN KINASE 6, 6-BROMO-7-{4-[(5-METHYLISOXAZOL-3-YL)METHYL]PIPERAZIN-1-YL}-2-[4-(4-METHYLPIPERAZIN-1-YL)PHENYL]-1H-IMIDAZO[4,5-B]PYRIDINE (2 entities in total)
機能のキーワードtransferase, mitosis, cell cycle
由来する生物種HOMO SAPIENS (HUMAN)
細胞内の位置Cytoplasm, cytoskeleton, microtubule organizing center, centrosome  O14965
ポリマー鎖数1
分子量合計33500.26
構造登録者
Kosmopoulou, M.,Bayliss, R. (登録日: 2010-02-17, 公開日: 2010-07-07, 最終更新日: 2018-02-28)
主引用文献
Bavetsias, V.,Large, J.M.,Sun, C.,Bouloc, N.,Kosmopoulou, M.,Matteucci, M.,Wilsher, N.E.,Martins, V.,Reynisson, J.,Atrash, B.,Faisal, A.,Urban, F.,Valenti, M.,de Haven Brandon, A.,Box, G.,Raynaud, F.I.,Workman, P.,Eccles, S.A.,Bayliss, R.,Blagg, J.,Linardopoulos, S.,McDonald, E.
Imidazo[4,5-b]pyridine derivatives as inhibitors of Aurora kinases: lead optimization studies toward the identification of an orally bioavailable preclinical development candidate.
J. Med. Chem., 53:5213-5228, 2010
PubMed: 20565112 (主引用文献が同じPDBエントリー)
DOI: 10.1021/jm100262j
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (3.35 Å)
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.228543.3%14.4%0.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
検証レポート(詳細版)をダウンロード