2X2R

Crystal structure of human kinesin Eg5 in complex with (R)-2-amino-3-((4-chlorophenyl)diphenylmethylthio)propanoic acid

Summary for 2X2R

Entry DOI	10.2210/pdb2x2r/pdb
Related	1II6 1Q0B 1X88 1YRS 2FKY 2FL2 2FL6 2G1Q 2GM1 2UYI 2UYM 2WOG
Descriptor	KINESIN-LIKE PROTEIN KIF11, ADENOSINE-5'-DIPHOSPHATE, (2R)-2-AMINO-3-[(2R)-2-METHYL-1,1-DIPHENYL-BUTYL]SULFANYL-PROPANOIC ACID, ... (5 entities in total)
Functional Keywords	mitosis, cell cycle, microtubule, atp-binding, motor protein, cell division
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cytoplasm: P52732
Total number of polymer chains	3
Total formula weight	125551.71
Authors	Kaan, H.Y.K.,Weiss, J.,Menger, D.,Ulaganathan, V.,Laggner, C.,Popowycz, F.,Joseph, B.,Kozielski, F. (deposition date: 2010-01-15, release date: 2011-01-26, Last modification date: 2023-12-20)
Primary citation	Kaan, H.Y.K.,Weiss, J.,Menger, D.,Ulaganathan, V.,Tkocz, K.,Laggner, C.,Popowycz, F.,Joseph, B.,Kozielski, F. Structure-Activity Relationship and Multidrug Resistance Study of New S-Trityl-L-Cysteine Derivatives as Inhibitors of Eg5. J.Med.Chem., 54:1576-, 2011 Cited by PubMed: 21344920 DOI: 10.1021/JM100991M PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation