2WIN

C3 convertase (C3bBb) stabilized by SCIN

Summary for 2WIN

• Entry DOI: 10.2210/pdb2win/pdb
• Related: 1DLE 1Q0P 1RRK 1RTK 2A73 2A74 2I6Q 2ICF 2QFF 2WII
• Descriptor: COMPLEMENT C3 BETA CHAIN, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (17 entities in total)
• Functional Keywords: serine protease, immune response, innate immunity, zymogen, secreted, protease, glycation, alternative pathway, disease mutation, hydrolase, convertase, complement, polymorphism, immune evasion, immune system
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Secreted: P01024 P01024 Q6GFB4
• Total number of polymer chains: 16
• Total formula weight: 984828.88

Authors

Wu, J.,Janssen, B.J.,Gros, P. (deposition date: 2009-05-13, release date: 2009-06-09, Last modification date: 2023-12-13)

• Primary citation: Rooijakkers, S.H.,Wu, J.,Ruyken, M.,van Domselaar, R.,Planken, K.L.,Tzekou, A.,Ricklin, D.,Lambris, J.D.,Janssen, B.J.,van Strijp, J.A.,Gros, P.; Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor.; Nat. Immunol., 10:721-727, 2009; PubMed: 19503103; DOI: 10.1038/ni.1756

Experimental method

X-RAY DIFFRACTION (3.9 Å)