2WII
Complement C3b in complex with factor H domains 1-4
Summary for 2WII
Entry DOI | 10.2210/pdb2wii/pdb |
Related | 1FHC 1HFH 1OJV 2A73 2A74 2G7I 2ICF 2JGW 2JGX 2RLP 2RLQ 2V8E 2W80 2W81 |
Descriptor | COMPLEMENT C3 BETA CHAIN, COMPLEMENT C3B ALPHA' CHAIN, COMPLEMENT FACTOR H, ... (8 entities in total) |
Functional Keywords | immune system, sushi, secreted, polymorphism, glycoprotein, complement system, complement pathway, immune response, innate immunity, disease mutation, inflammatory response, complement alternate pathway, cleavage on pair of basic residues, age-related macular degeneration, regulator of complement activation, alternative pathway, alternative splicing, phosphoprotein, disulfide bond, thioester bond |
Biological source | HOMO SAPIENS (HUMAN) More |
Cellular location | Secreted: P01024 P01024 |
Total number of polymer chains | 3 |
Total formula weight | 209591.19 |
Authors | Wu, J.,Janssen, B.J.C.,Gros, P. (deposition date: 2009-05-12, release date: 2009-06-09, Last modification date: 2023-12-13) |
Primary citation | Wu, J.,Wu, Y.Q.,Ricklin, D.,Janssen, B.J.,Lambris, J.D.,Gros, P. Structure of complement fragment C3b-factor H and implications for host protection by complement regulators. Nat. Immunol., 10:728-733, 2009 Cited by PubMed: 19503104DOI: 10.1038/ni.1755 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
Download full validation report