2VKM

Crystal structure of GRL-8234 bound to BACE (Beta-secretase)

2VKM の概要

• エントリーDOI: 10.2210/pdb2vkm/pdb
• 関連するPDBエントリー: 1FKN 1M4H 1PY1 1SGZ 1TQF 1UJJ 1UJK 1W50 1W51 1XN2 1XN3 1XS7 1YM2 1YM4 2B8L 2B8V 2VA5 2VA6 2VA7 2VIE 2VIJ 2VIY 2VIZ 2VJ6 2VJ7
• 分子名称: BETA-SECRETASE 1, N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-5-[methyl(methylsulfonyl)amino]-N'-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide (3 entities in total)
• 機能のキーワード: alternative splicing, aspartyl protease, aspartic protease, glycoprotein, transmembrane, beta secretase, app, bace, a-beta, x- ray, zymogen, membrane, protease, memapsin, hydrolase, alzheimer, drug design
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P56817
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 175886.45

構造登録者

Hong, L.,Tang, J.,Ghosh, A.K. (登録日: 2007-12-04, 公開日: 2008-12-16, 最終更新日: 2023-12-13)

• 主引用文献: Ghosh, A.K.,Kumaragurubaran, N.,Hong, L.,Kulkarni, S.,Xu, X.,Miller, H.B.,Reddy, D.S.,Weerasena, V.,Turner, R.,Chang, W.,Koelsch, G.,Tang, J.; Potent Memapsin 2 (Beta-Secretase) Inhibitors: Design, Synthesis, Protein-Ligand X-Ray Structure, and in Vivo Evaluation.; Bioorg.Med.Chem.Lett., 18:1031-, 2008; PubMed: 18180160; DOI: 10.1016/J.BMCL.2007.12.028

実験手法

X-RAY DIFFRACTION (2.05 Å)