2UYM
Crystal structure of KSP in complex with ADP and thiophene containing inhibitor 37
Summary for 2UYM
| Entry DOI | 10.2210/pdb2uym/pdb |
| Related | 1II6 1Q0B 1X88 1YRS 2FKY 2FL2 2FL6 2G1Q 2GM1 2UYI |
| Descriptor | KINESIN-LIKE PROTEIN KIF11, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (5 entities in total) |
| Functional Keywords | kinesin spindle protein, ksp, eg5, complex, inhibitor, thiophene, atp-binding, cell cycle, cell division, coiled coil, microtubule, mitosis, motor protein, nucleotide-binding, phosphorylation |
| Biological source | HOMO SAPIENS (HUMAN) |
| Cellular location | Cytoplasm: P52732 |
| Total number of polymer chains | 2 |
| Total formula weight | 83795.30 |
| Authors | Lee, T.T. (deposition date: 2007-04-10, release date: 2007-05-22, Last modification date: 2023-12-13) |
| Primary citation | Pinkerton, A.B.,Lee, T.T.,Hoffman, T.Z.,Wang, Y.,Kahraman, M.,Cook, T.G.,Severance, D.,Gahman, T.C.,Noble, S.A.,Shiau, A.K.,Davis, R.L. Synthesis and Sar of Thiophene Containing Kinesin Spindle Protein (Ksp) Inhibitors. Bioorg.Med.Chem.Lett., 17:3562-, 2007 Cited by PubMed Abstract: We have identified and synthesized a series of thiophene containing inhibitors of kinesin spindle protein. SAR studies led to the synthesis of 33, which was co-crystallized with KSP and determined to bind to an allosteric pocket previously described for other known KSP inhibitors. PubMed: 17498954DOI: 10.1016/J.BMCL.2007.04.076 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.11 Å) |
Structure validation
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