2UWD
Inhibition of the HSP90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole, isoxazole amide analogs
Summary for 2UWD
Entry DOI | 10.2210/pdb2uwd/pdb |
Related | 1BYQ 1OSF 1UY6 1UY7 1UY8 1UY9 1UYC 1UYD 1UYE 1UYF 1UYG 1UYH 1UYI 1UYK 1UYL 1YC1 1YC3 1YC4 1YER 1YES 1YET 2BSM 2BT0 2BUG 2BYH 2BYI 2BZ5 2C2L 2CCS 2CCT 2CCU 2CDD 2FWY 2FWZ |
Descriptor | HEAT SHOCK PROTEIN HSP 90-ALPHA, MAGNESIUM ION, SULFATE ION, ... (5 entities in total) |
Functional Keywords | chaperone, heat shock, atp-binding, phosphorylation, nucleotide-binding |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Nucleus : P07900 |
Total number of polymer chains | 1 |
Total formula weight | 27135.25 |
Authors | Sharp, S.Y.,Prodromou, C.,Boxall, K.,Powers, M.V.,Holmes, J.L.,Box, G.,Matthews, T.P.,Cheung, K.M.,Kalusa, A.,James, K.,Hayes, A.,Hardcastle, A.,Dymock, B.,Brough, P.A.,Barril, X.,Cansfield, J.E.,Wright, L.M.,Surgenor, A.,Foloppe, N.,Aherne, W.,Pearl, L.,Jones, K.,McDonald, E.,Raynaud, F.,Eccles, S.,Drysdale, M.,Workman, P. (deposition date: 2007-03-20, release date: 2007-04-24, Last modification date: 2023-12-13) |
Primary citation | Sharp, S.Y.,Prodromou, C.,Boxall, K.,Powers, M.V.,Holmes, J.L.,Box, G.,Matthews, T.P.,Cheung, K.M.,Kalusa, A.,James, K.,Hayes, A.,Hardcastle, A.,Dymock, B.,Brough, P.A.,Barril, X.,Cansfield, J.E.,Wright, L.,Surgenor, A.,Foloppe, N.,Hubbard, R.E.,Aherne, W.,Pearl, L.,Jones, K.,McDonald, E.,Raynaud, F.,Eccles, S.,Drysdale, M.,Workman, P. Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues. Mol. Cancer Ther., 6:1198-1211, 2007 Cited by PubMed: 17431102DOI: 10.1158/1535-7163.MCT-07-0149 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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