2JIX

Crystal structure of ABT-007 FAB fragment with the soluble domain of EPO receptor

Summary for 2JIX

• Entry DOI: 10.2210/pdb2jix/pdb
• Related: 1CN4 1EBA 1EBP 1EER 1ERN
• Descriptor: ABT-007 FAB FRAGMENT, ERYTHROPOIETIN RECEPTOR (3 entities in total)
• Functional Keywords: immune system, receptor, transmembrane, receptor soluble domain, antibody, receptor-immune system complex, receptor/immune system
• Biological source: HOMO SAPIENS (HUMAN); More
• Total number of polymer chains: 9
• Total formula weight: 213148.86

Authors

Liu, Z.,Stoll, V.S.,DeVries, P.,Jakob, C.G.,Xie, N.,Simmer, R.L.,Lacy, S.E.,Egan, D.A.,Harlan, J.E.,Lesniewski, R.R.,Reilly, E.B. (deposition date: 2007-07-02, release date: 2007-07-10, Last modification date: 2020-03-18)

• Primary citation: Liu, Z.,Stoll, V.S.,Devries, P.,Jakob, C.G.,Xie, N.,Simmer, R.L.,Lacy, S.E.,Egan, D.A.,Harlan, J.E.,Lesniewski, R.R.,Reilly, E.B.; A Potent Erythropoietin-Mimicking Human Antibody Interacts Through a Novel Binding Site.; Blood, 110:2408-, 2007; PubMed: 17620453; DOI: 10.1182/BLOOD-2007-04-083998

Experimental method

X-RAY DIFFRACTION (3.2 Å)