2JIX

Crystal structure of ABT-007 FAB fragment with the soluble domain of EPO receptor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002250	biological_process	adaptive immune response
A	0002376	biological_process	immune system process
A	0005576	cellular_component	extracellular region
A	0005886	cellular_component	plasma membrane
A	0019814	cellular_component	immunoglobulin complex
B	0004896	molecular_function	cytokine receptor activity
B	0016020	cellular_component	membrane
C	0004896	molecular_function	cytokine receptor activity
C	0016020	cellular_component	membrane
E	0004896	molecular_function	cytokine receptor activity
E	0016020	cellular_component	membrane
G	0002250	biological_process	adaptive immune response
G	0002376	biological_process	immune system process
G	0005576	cellular_component	extracellular region
G	0005886	cellular_component	plasma membrane
G	0019814	cellular_component	immunoglobulin complex
L	0002250	biological_process	adaptive immune response
L	0002376	biological_process	immune system process
L	0005576	cellular_component	extracellular region
L	0005886	cellular_component	plasma membrane
L	0019814	cellular_component	immunoglobulin complex

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH

Chain	Residue	Details
A	TYR192-HIS198
D	TYR197-HIS203

---

site_id	PS01352
Number of Residues	81
Details	HEMATOPO_REC_L_F1 Long hematopoietin receptor, single chain family signature. VvLrWlpppetpmtshir...YEVdvsagngagsvqrveilegrtecvlsnLrgrtrytfavRaRmaepsfggfWsaWsepvsL

Chain	Residue	Details
B	VAL138-LEU218

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI2
Number of Residues	300
Details	Domain: {"description":"Fibronectin type-III","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	12
Details	Motif: {"description":"WSXWS motif","evidences":[{"source":"PubMed","id":"9774108","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Site: {"description":"Required for ligand binding","evidences":[{"source":"PubMed","id":"8662939","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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