2JIV
Crystal structure of EGFR kinase domain T790M mutation in compex with HKI-272
Summary for 2JIV
Entry DOI | 10.2210/pdb2jiv/pdb |
Related | 1DNQ 1DNR 1IVO 1M14 1M17 1MOX 1NQL 1XKK 1YY9 1Z9I 2GS2 2GS7 2ITN 2ITO 2ITP 2ITQ 2ITT 2ITU 2ITV 2ITW 2ITX 2ITY 2ITZ 2J5E 2J5F 2J6M 2JIT 2JIU |
Descriptor | EPIDERMAL GROWTH FACTOR RECEPTOR, N-(4-{[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)butanamide, CHLORIDE ION, ... (4 entities in total) |
Functional Keywords | hki272, hki-272, receptor, cell cycle, atp-binding, transferase, tyrosine-protein kinase, transmembrane, phosphorylation, disease mutation, nucleotide-binding, anti-oncogene, epidermal growth factor |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533 |
Total number of polymer chains | 2 |
Total formula weight | 76031.63 |
Authors | Yun, C.-H.,Mengwasser, K.E.,Toms, A.V.,Li, Y.,Woo, M.S.,Greulich, H.,Wong, K.-K.,Meyerson, M.,Eck, M.J. (deposition date: 2007-07-02, release date: 2008-01-22, Last modification date: 2023-12-13) |
Primary citation | Yun, C.-H.,Mengwasser, K.E.,Toms, A.V.,Woo, M.S.,Greulich, H.,Wong, K.-K.,Meyerson, M.,Eck, M.J. The T790M Mutation in Egfr Kinase Causes Drug Resistance by Increasing the Affinity for ATP. Proc.Natl.Acad.Sci.USA, 105:2070-, 2008 Cited by PubMed: 18227510DOI: 10.1073/PNAS.0709662105 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.5 Å) |
Structure validation
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