1MOX

Crystal Structure of Human Epidermal Growth Factor Receptor (residues 1-501) in complex with TGF-alpha

Summary for 1MOX

Entry DOI	10.2210/pdb1mox/pdb
Related	1IGR 1M6B 2TGF
Descriptor	Epidermal Growth Factor Receptor, 2-acetamido-2-deoxy-beta-D-glucopyranose, Transforming Growth Factor alpha, ... (11 entities in total)
Functional Keywords	egfr, receptor, complex, growth factor, transferase-growth factor complex, transferase/growth factor
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	127948.54
Authors	Garrett, T.P.J.,McKern, N.M.,Lou, M.,Elleman, T.C.,Adams, T.E.,Lovrecz, G.O.,Zhu, H.-J.,Walker, F.,Frenkel, M.J.,Hoyne, P.A.,Jorissen, R.N.,Nice, E.C.,Burgess, A.W.,Ward, C.W. (deposition date: 2002-09-10, release date: 2003-09-10, Last modification date: 2020-07-29)
Primary citation	Garrett, T.P.J.,McKern, N.M.,Lou, M.,Elleman, T.C.,Adams, T.E.,Lovrecz, G.O.,Zhu, H.-J.,Walker, F.,Frenkel, M.J.,Hoyne, P.A.,Jorissen, R.N.,Nice, E.C.,Burgess, A.W.,Ward, C.W. Crystal Structure of a Truncated Epidermal Growth Factor Receptor Extracellular Domain Bound to Transforming Growth Factor alpha Cell(Cambridge,Mass.), 110:763-773, 2002 Cited by PubMed: 12297049 DOI: 10.1016/S0092-8674(02)00940-6 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation