2ITW

Crystal structure of EGFR kinase domain in complex with AFN941

Summary for 2ITW

Related1DNQ 1DNR 1IVO 1M14 1M17 1MOX 1NQL 1XKK 1YY9 1Z9I 2ITN 2ITO 2ITP 2ITQ 2ITT 2ITU 2ITV 2ITX 2ITY 2ITZ
DescriptorEPIDERMAL GROWTH FACTOR RECEPTOR, 1,2,3,4-Tetrahydrogen Staurosporine (3 entities in total)
Functional Keywordsreceptor, cell cycle, atp-binding, transferase, transmembrane, phosphorylation, disease mutation, polymorphism, glycoprotein, anti-oncogene, nucleotide-binding, alternative splicing, afn941, egfr, kinase, staurosporine, membrane, tyrosine-protein kinase, epidermal growth factor
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationCell membrane; Single-pass type I membrane protein. Isoform 2: Secreted P00533
Total number of polymer chains1
Total molecular weight37772.68
Authors
Yun, C.-H.,Boggon, T.J.,Li, Y.,Woo, S.,Greulich, H.,Meyerson, M.,Eck, M.J. (deposition date: 2006-05-25, release date: 2007-04-03, Last modification date: 2013-03-27)
Primary citation
Yun, C.-H.,Boggon, T.J.,Li, Y.,Woo, S.,Greulich, H.,Meyerson, M.,Eck, M.J.
Structures of Lung Cancer-Derived Egfr Mutants and Inhibitor Complexes: Mechanism of Activation and Insights Into Differential Inhibitor Sensitivity
Cancer Cell, 11:217-, 2007
PubMed: 17349580 (PDB entries with the same primary citation)
DOI: 10.1016/J.CCR.2006.12.017
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.88 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.253184.7%10.7%5.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution