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2ITP

Crystal structure of EGFR kinase domain G719S mutation in complex with AEE788

Summary for 2ITP
Entry DOI10.2210/pdb2itp/pdb
Related1XKK 2ITN 2ITO 2ITQ 2ITT 2ITU 2ITV 2ITW 2ITX 2ITY 2ITZ
DescriptorEPIDERMAL GROWTH FACTOR RECEPTOR PRECURSOR, 6-{4-[(4-ETHYLPIPERAZIN-1-YL)METHYL]PHENYL}-N-[(1R)-1-PHENYLETHYL]-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE (3 entities in total)
Functional Keywordsreceptor, cell cycle, atp-binding, transferase, transmembrane, phosphorylation, disease mutation, polymorphism, glycoprotein, anti-oncogene, nucleotide-binding, alternative splicing, aee788, egfr, g719s, kinase, membrane, tyrosine-protein kinase, epidermal growth factor
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationCell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
Total number of polymer chains1
Total formula weight37774.74
Authors
Yun, C.-H.,Boggon, T.J.,Li, Y.,Woo, S.,Greulich, H.,Meyerson, M.,Eck, M.J. (deposition date: 2006-05-25, release date: 2007-04-03, Last modification date: 2023-12-13)
Primary citationYun, C.-H.,Boggon, T.J.,Li, Y.,Woo, S.,Greulich, H.,Meyerson, M.,Eck, M.J.
Structures of Lung Cancer-Derived Egfr Mutants and Inhibitor Complexes: Mechanism of Activation and Insights Into Differential Inhibitor Sensitivity
Cancer Cell, 11:217-, 2007
Cited by
PubMed: 17349580
DOI: 10.1016/J.CCR.2006.12.017
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.74 Å)
Structure validation

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