1XKK
EGFR kinase domain complexed with a quinazoline inhibitor- GW572016
Summary for 1XKK
Entry DOI | 10.2210/pdb1xkk/pdb |
Descriptor | Epidermal growth factor receptor, PHOSPHATE ION, N-{3-CHLORO-4-[(3-FLUOROBENZYL)OXY]PHENYL}-6-[5-({[2-(METHYLSULFONYL)ETHYL]AMINO}METHYL)-2-FURYL]-4-QUINAZOLINAMINE, ... (4 entities in total) |
Functional Keywords | egfr, epidermal growth factor receptor, kinase, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533 |
Total number of polymer chains | 1 |
Total formula weight | 41095.41 |
Authors | Wood, E.R.,Truesdale, A.T.,McDonald, O.B.,Yuan, D.,Hassell, A.,Dickerson, S.H.,Ellis, B.,Pennisi, C.,Horne, E.,Lackey, K.,Alligood, K.J.,Rusnak, D.W.,Gilmer, T.M.,Shewchuk, L.M. (deposition date: 2004-09-29, release date: 2004-12-07, Last modification date: 2023-08-23) |
Primary citation | Wood, E.R.,Truesdale, A.T.,McDonald, O.B.,Yuan, D.,Hassell, A.,Dickerson, S.H.,Ellis, B.,Pennisi, C.,Horne, E.,Lackey, K.,Alligood, K.J.,Rusnak, D.W.,Gilmer, T.M.,Shewchuk, L. A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells. Cancer Res., 64:6652-6659, 2004 Cited by PubMed: 15374980DOI: 10.1158/0008-5472.CAN-04-1168 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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