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1XKK

EGFR kinase domain complexed with a quinazoline inhibitor- GW572016

Summary for 1XKK
Entry DOI10.2210/pdb1xkk/pdb
DescriptorEpidermal growth factor receptor, PHOSPHATE ION, N-{3-CHLORO-4-[(3-FLUOROBENZYL)OXY]PHENYL}-6-[5-({[2-(METHYLSULFONYL)ETHYL]AMINO}METHYL)-2-FURYL]-4-QUINAZOLINAMINE, ... (4 entities in total)
Functional Keywordsegfr, epidermal growth factor receptor, kinase, transferase
Biological sourceHomo sapiens (human)
Cellular locationCell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
Total number of polymer chains1
Total formula weight41095.41
Authors
Primary citationWood, E.R.,Truesdale, A.T.,McDonald, O.B.,Yuan, D.,Hassell, A.,Dickerson, S.H.,Ellis, B.,Pennisi, C.,Horne, E.,Lackey, K.,Alligood, K.J.,Rusnak, D.W.,Gilmer, T.M.,Shewchuk, L.
A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells.
Cancer Res., 64:6652-6659, 2004
Cited by
PubMed: 15374980
DOI: 10.1158/0008-5472.CAN-04-1168
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.4 Å)
Structure validation

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