1XKK
EGFR kinase domain complexed with a quinazoline inhibitor- GW572016
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Epidermal growth factor receptor | polymer | 352 | 40324.4 | 1 | UniProt (P00533) Pfam (PF07714) | Homo sapiens (human) | Receptor protein-tyrosine kinase ErbB-1 |
| 2 | B, C (A) | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
| 3 | D (A) | N-{3-CHLORO-4-[(3-FLUOROBENZYL)OXY]PHENYL}-6-[5-({[2-(METHYLSULFONYL)ETHYL]AMINO}METHYL)-2-FURYL]-4-QUINAZOLINAMINE | non-polymer | 581.1 | 1 | Chemie (FMM) | |||
| 4 | E (A) | water | water | 18.0 | 77 | Chemie (HOH) |
Sequence modifications
A: 695 - 1022 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Met 671 | - | initiating methionine |
| Lys 672 | - | cloning artifact |
| Lys 673 | - | cloning artifact |
| Gly 674 | - | cloning artifact |
| His 675 | - | expression tag |
| His 676 | - | expression tag |
| His 677 | - | expression tag |
| His 678 | - | expression tag |
| His 679 | - | expression tag |
| His 680 | - | expression tag |
| Asp 681 | - | cloning artifact |
| Tyr 682 | - | cloning artifact |
| Asp 683 | - | cloning artifact |
| Ile 684 | - | cloning artifact |
| Pro 685 | - | cloning artifact |
| Thr 686 | - | cloning artifact |
| Thr 687 | - | cloning artifact |
| Glu 688 | - | cloning artifact |
| Asn 689 | - | cloning artifact |
| Leu 690 | - | cloning artifact |
| Tyr 691 | - | cloning artifact |
| Phe 692 | - | cloning artifact |
| Gln 693 | - | cloning artifact |
| Gly 694 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 40324.4 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 771.0 | |
| All* | Total formula weight | 41095.4 |
