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2ITP

Crystal structure of EGFR kinase domain G719S mutation in complex with AEE788

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
EPIDERMAL GROWTH FACTOR RECEPTOR PRECURSORpolymer32737334.21UniProt (P00533)
Pfam (PF07714)
HOMO SAPIENS (HUMAN)RECEPTOR TYROSINE-PROTEIN KINASE ERBB-1
2B
(A)
6-{4-[(4-ETHYLPIPERAZIN-1-YL)METHYL]PHENYL}-N-[(1R)-1-PHENYLETHYL]-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINEnon-polymer440.61Chemie (AEE)
3C
(A)
waterwater18.065Chemie (HOH)
Sequence modifications
A: 696 - 1022 (UniProt: P00533)
PDBExternal DatabaseDetails
Ser 719Gly 719engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight37334.2
Non-Polymers*Number of molecules1
Total formula weight440.6
All*Total formula weight37774.7
*Water molecules are not included.

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PDB entries from 2024-10-30

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