1YY9

Structure of the extracellular domain of the epidermal growth factor receptor in complex with the Fab fragment of cetuximab/Erbitux/IMC-C225

Summary for 1YY9

• Entry DOI: 10.2210/pdb1yy9/pdb
• Related: 1YY8
• Descriptor: Epidermal Growth Factor Receptor, Cetuximab Fab Light chain, Cetuximab Fab Heavy chain, ... (7 entities in total)
• Functional Keywords: cell surface receptor; tyrosine kinase; glycoprotein; antigen:antibody complex; fab fragment; antitumor; drug, immune system-transferase complex, immune system/transferase
• Biological source: Homo sapiens (human); More
• Cellular location: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
• Total number of polymer chains: 3
• Total formula weight: 120235.81

Authors

Li, S.,Schmitz, K.R.,Jeffrey, P.D.,Wiltzius, J.J.W.,Kussie, P.,Ferguson, K.M. (deposition date: 2005-02-24, release date: 2005-04-26, Last modification date: 2023-08-23)

• Primary citation: Li, S.,Schmitz, K.R.,Jeffrey, P.D.,Wiltzius, J.J.W.,Kussie, P.,Ferguson, K.M.; Structural basis for inhibition of the epidermal growth factor receptor by cetuximab; Cancer Cell, 7:301-311, 2005; PubMed: 15837620; DOI: 10.1016/j.ccr.2005.03.003

Experimental method

X-RAY DIFFRACTION (2.605 Å)