1YY9
Structure of the extracellular domain of the epidermal growth factor receptor in complex with the Fab fragment of cetuximab/Erbitux/IMC-C225
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Epidermal Growth Factor Receptor | polymer | 624 | 69284.0 | 1 | UniProt (P00533) Pfam (PF01030) Pfam (PF00757) Pfam (PF14843) In PDB | Homo sapiens (human) | Receptor tyrosine-protein kinase ErbB-1 |
2 | C | Cetuximab Fab Light chain | polymer | 213 | 23287.7 | 1 | Mus musculus Homo sapiens (house mouse human) | ||
3 | D | Cetuximab Fab Heavy chain | polymer | 221 | 23725.5 | 1 | Mus musculus Homo sapiens (house mouse human) | ||
4 | B | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1559.4 | 1 | In PDB GlyTouCan (G52461YB) | |||
5 | E, F, G | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 3 | In PDB GlyTouCan (G42666HT) | |||
6 | A, D | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 5 | Chemie (NAG) | |||
7 | water | water | 18.0 | 56 | Chemie (HOH) |
Sequence modifications
A: 1 - 618 (UniProt: P00533)
PDB | External Database | Details |
---|---|---|
Lys 474 | Ser 498 | conflict |
Arg 610 | Glu 634 | conflict |
His 619 | - | expression tag |
His 620 | - | expression tag |
His 621 | - | expression tag |
His 622 | - | expression tag |
His 623 | - | expression tag |
His 624 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 116297.2 | |
Branched | Number of molecules | 4 |
Total formula weight | 2832.6 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 1106.0 | |
All* | Total formula weight | 120235.8 |