1YY9

Structure of the extracellular domain of the epidermal growth factor receptor in complex with the Fab fragment of cetuximab/Erbitux/IMC-C225

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Epidermal Growth Factor Receptor	polymer	624	69284.0	1	UniProt (P00533) Pfam (PF01030) Pfam (PF00757) Pfam (PF14843)	Homo sapiens (human)	Receptor tyrosine-protein kinase ErbB-1
2	B (C)	Cetuximab Fab Light chain	polymer	213	23287.7	1		Mus musculus Homo sapiens (house mouse human)
3	C (D)	Cetuximab Fab Heavy chain	polymer	221	23725.5	1		Mus musculus Homo sapiens (house mouse human)
4	D (B)	alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1559.4	1	In PDB GlyTouCan (G52461YB)
5	E, F, G (E, F, G)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	3	In PDB GlyTouCan (G42666HT)
6	H, I, J, K, L (A, D)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	5	Chemie (NAG)
7	M, N, O (A, C, D)	water	water		18.0	56	Chemie (HOH)

Sequence modifications

A: 1 - 618 (UniProt: P00533)

PDB	External Database	Details
Lys 474	Ser 498	conflict
Arg 610	Glu 634	conflict
His 619	-	expression tag
His 620	-	expression tag
His 621	-	expression tag
His 622	-	expression tag
His 623	-	expression tag
His 624	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	116297.2
Branched	Number of molecules	4
	Total formula weight	2832.6
Non-Polymers*	Number of molecules	5
	Total formula weight	1106.0
All*	Total formula weight	120235.8

*Water molecules are not included.