2JIV
Crystal structure of EGFR kinase domain T790M mutation in compex with HKI-272
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | EPIDERMAL GROWTH FACTOR RECEPTOR | polymer | 328 | 37421.3 | 2 | UniProt (P00533) Pfam (PF07714) | HOMO SAPIENS (HUMAN) | RECEPTOR TYROSINE-PROTEIN KINASE ERBB-1 |
| 2 | C, D (A, B) | N-(4-{[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)butanamide | non-polymer | 559.1 | 2 | Chemie (HKI) | |||
| 3 | E, F (B) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 62 | Chemie (HOH) |
Sequence modifications
A, B: 695 - 1022 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Met 790 | Thr 790 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 74842.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1189.0 | |
| All* | Total formula weight | 76031.6 |
