2J6M
Crystal structure of EGFR kinase domain in complex with AEE788
Summary for 2J6M
Entry DOI | 10.2210/pdb2j6m/pdb |
Related | 1DNQ 1DNR 1IVO 1M14 1M17 1MOX 1NQL 1XKK 1YY9 1Z9I 2GS2 2GS7 2ITN 2ITO 2ITP 2ITQ 2ITT 2ITU 2ITV 2ITW 2ITX 2ITY 2ITZ 2J5E 2J5F |
Descriptor | EPIDERMAL GROWTH FACTOR RECEPTOR, 6-{4-[(4-ETHYLPIPERAZIN-1-YL)METHYL]PHENYL}-N-[(1R)-1-PHENYLETHYL]-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE (3 entities in total) |
Functional Keywords | cell cycle, atp-binding, transferase, polymorphism, nucleotide-binding, alternative splicing, tyrosine-protein kinase, epidermal growth factor, ubl conjugation, phosphorylation, disease mutation, glycoprotein, anti-oncogene, transmembrane, egfr, kinase, aee788, membrane, receptor, wild-type |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533 |
Total number of polymer chains | 1 |
Total formula weight | 37744.71 |
Authors | Yun, C.-H.,Boggon, T.J.,Li, Y.,Woo, S.,Greulich, H.,Meyerson, M.,Eck, M.J. (deposition date: 2006-09-29, release date: 2007-04-03, Last modification date: 2023-12-13) |
Primary citation | Yun, C.-H.,Boggon, T.J.,Li, Y.,Woo, S.,Greulich, H.,Meyerson, M.,Eck, M.J. Structures of Lung Cancer-Derived Egfr Mutants and Inhibitor Complexes: Mechanism of Activation and Insights Into Differential Inhibitor Sensitivity Cancer Cell, 11:217-, 2007 Cited by PubMed: 17349580DOI: 10.1016/J.CCR.2006.12.017 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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