2GFD
GRP94 in complex with the novel HSP90 Inhibitor Radamide
Summary for 2GFD
Entry DOI | 10.2210/pdb2gfd/pdb |
Related | 1OSF 1QY8 1U0Z 1ZWH 2FXS 2FYP |
Descriptor | Endoplasmin, METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATE, TETRAETHYLENE GLYCOL, ... (5 entities in total) |
Functional Keywords | grp94, hsp82, hsp90, htpg, chaperone, ligand, radicicol, geldanamycin, radester, radamide |
Biological source | Canis lupus familiaris (dog) More |
Cellular location | Endoplasmic reticulum lumen: P41148 |
Total number of polymer chains | 2 |
Total formula weight | 54866.79 |
Authors | Immormino, R.M.,Gewirth, D.T. (deposition date: 2006-03-21, release date: 2007-04-03, Last modification date: 2023-08-30) |
Primary citation | Immormino, R.M.,Metzger, L.E.,Reardon, P.N.,Dollins, D.E.,Blagg, B.S.,Gewirth, D.T. Different poses for ligand and chaperone in inhibitor-bound Hsp90 and GRP94: implications for paralog-specific drug design. J.Mol.Biol., 388:1033-1042, 2009 Cited by PubMed: 19361515DOI: 10.1016/j.jmb.2009.03.071 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
Download full validation report