2B1G

Crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase

2B1G の概要

• エントリーDOI: 10.2210/pdb2b1g/pdb
• 関連するPDBエントリー: 1G8M 1M9N 1OZ0 1PKX 1PL0 1THZ 2b0w 2b1i
• 分子名称: Bifunctional purine biosynthesis protein PURH, PHOSPHATE ION, POTASSIUM ION, ... (5 entities in total)
• 機能のキーワード: atic, impch, structure-base, transition state analogue, inhibitor, transferase, hydrolase
• 由来する生物種: Gallus gallus (chicken)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 258977.70

構造登録者

Xu, L.,Chong, Y.,Hwang, I.,D'Onofrio, A.,Amore, K.,Beardsley, G.P.,Li, C.,Olson, A.J.,Boger, D.L.,Wilson, I.A. (登録日: 2005-09-15, 公開日: 2006-11-21, 最終更新日: 2023-08-23)

• 主引用文献: Xu, L.,Chong, Y.,Hwang, I.,D'Onofrio, A.,Amore, K.,Beardsley, G.P.,Li, C.,Olson, A.J.,Boger, D.L.,Wilson, I.A.; Structure-based Design, Synthesis, Evaluation, and Crystal Structures of Transition State Analogue Inhibitors of Inosine Monophosphate Cyclohydrolase.; J.Biol.Chem., 282:13033-13046, 2007; PubMed: 17324932; DOI: 10.1074/jbc.M607293200

実験手法

X-RAY DIFFRACTION (2.1 Å)