1PL0

Crystal structure of human ATIC in complex with folate-based inhibitor, BW2315U89UC

Summary for 1PL0

Entry DOI	10.2210/pdb1pl0/pdb
Related	1P4R 1PKX
Descriptor	Bifunctional purine biosynthesis protein PURH, POTASSIUM ION, XANTHOSINE-5'-MONOPHOSPHATE, ... (6 entities in total)
Functional Keywords	human atic, aicar, aicar transformylase, imp cyclohydrolase, xanthosine monophosphate, folate-based inhibitor, bw2315u89uc, transferase, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	261655.24
Authors	Cheong, C.G.,Greasley, S.E.,Horton, P.A.,Beardsley, G.P.,Wilson, I.A. (deposition date: 2003-06-06, release date: 2004-04-27, Last modification date: 2023-08-16)
Primary citation	Cheong, C.G.,Wolan, D.W.,Greasley, S.E.,Horton, P.A.,Beardsley, G.P.,Wilson, I.A. Crystal Structures of Human Bifunctional Enzyme Aminoimidazole-4-carboxamide Ribonucleotide Transformylase/IMP Cyclohydrolase in Complex with Potent Sulfonyl-containing Antifolates. J.Biol.Chem., 279:18034-18045, 2004 Cited by PubMed: 14966129 DOI: 10.1074/jbc.M313691200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation