1PL0
Crystal structure of human ATIC in complex with folate-based inhibitor, BW2315U89UC
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Bifunctional purine biosynthesis protein PURH | polymer | 592 | 64693.7 | 4 | UniProt (P31939) Pfam (PF02142) Pfam (PF01808) | Homo sapiens (human) | ATIC |
| 2 | E, G, J, L (A, B, C, D) | POTASSIUM ION | non-polymer | 39.1 | 4 | Chemie (K) | |||
| 3 | F, K (A, C) | XANTHOSINE-5'-MONOPHOSPHATE | non-polymer | 365.2 | 2 | Chemie (XMP) | |||
| 4 | H, M, N (B, D) | AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE | non-polymer | 338.2 | 3 | Chemie (AMZ) | |||
| 5 | I, O (B, D) | N-(4-{[(2-AMINO-4-OXO-3,4-DIHYDROQUINAZOLIN-6-YL)AMINO]SULFONYL}BENZOYL)GLUTAMIC ACID | non-polymer | 489.5 | 2 | Chemie (BW2) | |||
| 6 | P, Q, R, S (A, B, C, D) | water | water | 18.0 | 388 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 258774.9 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 2880.4 | |
| All* | Total formula weight | 261655.2 |
