1OZ0

CRYSTAL STRUCTURE OF THE HOMODIMERIC BIFUNCTIONAL TRANSFORMYLASE AND CYCLOHYDROLASE ENZYME AVIAN ATIC IN COMPLEX WITH A MULTISUBSTRATE ADDUCT INHIBITOR BETA-DADF.

Summary for 1OZ0

Entry DOI	10.2210/pdb1oz0/pdb
Related	1G8M 1M9N
Descriptor	Bifunctional purine biosynthesis protein PURH, POTASSIUM ION, PHOSPHATE ION, ... (5 entities in total)
Functional Keywords	homodimer, 2 functional domains, impch domain = alpha/beta/alpha, aicar tfase = 2 alpha/beta/alpha domains, 1 alpha + beta domain, transferase, hydrolase
Biological source	Gallus gallus (chicken)
Total number of polymer chains	2
Total formula weight	135237.58
Authors	Wolan, D.W.,Greasley, S.E.,Wall, M.J.,Benkovic, S.J.,Wilson, I.A. (deposition date: 2003-04-07, release date: 2003-09-30, Last modification date: 2023-08-16)
Primary citation	Wolan, D.W.,Greasley, S.E.,Wall, M.J.,Benkovic, S.J.,Wilson, I.A. Structure of Avian AICAR Transformylase with a Multisubstrate Adduct Inhibitor beta-DADF Identifies the Folate Binding Site. Biochemistry, 42:10904-10914, 2003 Cited by PubMed: 12974624 DOI: 10.1021/bi030106h PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation