2UZE

Crystal structure of human CDK2 complexed with a thiazolidinone inhibitor

2UZE の概要

• エントリーDOI: 10.2210/pdb2uze/pdb
• 関連するPDBエントリー: 1E9H 1FIN 1FVV 1GY3 1H1P 1H1Q 1H1R 1H1S 1H24 1H25 1H26 1H27 1H28 1JST 1JSU 1OGU 1OI9 1OIU 1OIY 1OKV 1OKW 1OL1 1OL2 1P5E 1PKD 1QMZ 1URC 1VYW 2BKZ 2BPM 2C4G 2C5N 2C5O 2C5P 2C5T 2C5V 2C5X 2C6T 2CCH 2CCI 2CJM 2IW6 2IW8 2IW9 2UUE 2UZB 2UZD 2UZL 2UZN 2UZO
• 分子名称: CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, 4-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]FURAN-2-YL}BENZOIC ACID, ... (4 entities in total)
• 機能のキーワード: transferase, atp-binding, phosphorylation, cdk2, kinase, cyclin, mitosis, cell cycle, cell division, nucleotide-binding, serine/threonine-protein kinase, thiazolidinone ligand
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 127990.16

構造登録者

Richardson, C.M.,Dokurno, P.,Murray, J.B.,Surgenor, A.E. (登録日: 2007-04-27, 公開日: 2007-06-26, 最終更新日: 2019-04-03)

• 主引用文献: Richardson, C.M.,Nunns, C.L.,Williamson, D.S.,Parratt, M.J.,Dokurno, P.,Howes, R.,Borgognoni, J.,Drysdale, M.J.,Finch, H.,Hubbard, R.E.,Jackson, P.S.,Kierstan, P.,Lentzen, G.,Moore, J.D.,Murray, J.B.,Simmonite, H.,Surgenor, A.E.,Torrance, C.J.; Discovery of a Potent Cdk2 Inhibitor with a Novel Binding Mode, Using Virtual Screening and Initial, Structure-Guided Lead Scoping.; Bioorg.Med.Chem.Lett., 17:3880-, 2007; PubMed: 17570665; DOI: 10.1016/J.BMCL.2007.04.110

実験手法

X-RAY DIFFRACTION (2.4 Å)