2BYI

3-(5-chloro-2,4-dihydroxyphenyl)-pyrazole-4-carboxamides as Inhibitors of the Hsp90 Molecular Chaperone

2BYI の概要

• エントリーDOI: 10.2210/pdb2byi/pdb
• 関連するPDBエントリー: 1BYQ 1OSF 1UY6 1UY7 1UY8 1UY9 1UYC 1UYD 1UYE 1UYF 1UYG 1UYH 1UYI 1UYK 1UYL 1YC1 1YC3 1YC4 1YER 1YES 1YET 2BSM 2BT0 2BYH
• 分子名称: HEAT SHOCK PROTEIN HSP90-ALPHA, 3-(5-CHLORO-2,4-DIHYDROXY-PHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID 4-SULFAMOYL-BENZYLAMIDE (3 entities in total)
• 機能のキーワード: pyrazole, hsp90, chaperone, atp-binding, heat shock, nucleotide-binding, phosphorylation
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Cytoplasm: P07900
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 26893.42

構造登録者

Brough, P.A.,Barril, X.,Beswick, M.,Dymock, B.W.,Drysdale, M.J.,Wright, L.,Grant, K.,Massey, A.,Surgenor, A.,Workman, P. (登録日: 2005-08-02, 公開日: 2005-10-12, 最終更新日: 2023-12-13)

• 主引用文献: Brough, P.A.,Barril, X.,Beswick, M.,Dymock, B.W.,Drysdale, M.J.,Wright, L.,Grant, K.,Massey, A.,Surgenor, A.,Workman, P.; 3-(5-Chloro-2,4-Dihydroxyphenyl)-Pyrazole-4-Carboxamides as Inhibitors of the Hsp90 Molecular Chaperone.; Bioorg.Med.Chem.Lett., 15:5197-, 2005; PubMed: 16213716; DOI: 10.1016/J.BMCL.2005.08.091

実験手法

X-RAY DIFFRACTION (1.6 Å)