Crystal structure of the complex of mutant HIV-1 protease (A71V, V82T, I84V) with a hydroxyethylamine peptidomimetic inhibitor BOC-PHE-PSI[R-CH(OH)CH2NH]-PHE-GLU-PHE-NH2

Summary for 1ZPK

Related1FQX 1M0B 1LZQ 1IIQ 1Z8C 1ZBG 1ZJ7 1ZLF 1ZSF 1ZSR
Related PRD IDPRD_000385
DescriptorPROTEASE RETROPEPSIN, N-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-4-phenylbutyl}-L-phenylalanyl-L-alpha-glutamyl-L-phenylalaninamide, CHLORIDE ION, ... (5 entities in total)
Functional Keywordshiv, protease, peptidomimetic inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHuman immunodeficiency virus 1
Cellular locationMatrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential) P03367
Total number of polymer chains2
Total molecular weight22554.02
Duskova, J.,Skalova, T.,Dohnalek, J.,Petrokova, H.,Hasek, J. (deposition date: 2005-05-17, release date: 2006-04-25, Last modification date: 2012-12-12)
Primary citation
Duskova, J.,Skalova, T.,Dohnalek, J.,Petrokova, H.,Hasek, J.
Mutational Study of Pseudopeptide Inhibitor Binding to HIV-1 Protease; Analysis of Four X-ray Structures
To be Published,
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers1005.4%3.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-07-29