1ZPK
Crystal structure of the complex of mutant HIV-1 protease (A71V, V82T, I84V) with a hydroxyethylamine peptidomimetic inhibitor BOC-PHE-PSI[R-CH(OH)CH2NH]-PHE-GLU-PHE-NH2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | PROTEASE RETROPEPSIN | polymer | 99 | 10895.9 | 2 | UniProt (P03367) Pfam (PF00077) UniProt (by SIFTS) (Q7ZCL6) In PDB | Human immunodeficiency virus 1 | HIV-1 PROTEASE |
| 2 | A | N-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-4-phenylbutyl}-L-phenylalanyl-L-alpha-glutamyl-L-phenylalaninamide | non-polymer | 703.8 | 1 | BIRD (PRD_000385) Chemie (0ZS) | |||
| 3 | B | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 4 | B | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 5 | water | water | 18.0 | 160 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: P03367)
| PDB | External Database | Details |
|---|---|---|
| Val 71 | Ala 139 | engineered mutation |
| Thr 82 | Val 150 | engineered mutation |
| Val 84 | Ile 152 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21791.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 762.3 | |
| All* | Total formula weight | 22554.0 |
