1W82

p38 Kinase crystal structure in complex with small molecule inhibitor

Summary for 1W82

Entry DOI	10.2210/pdb1w82/pdb
Related	1A9U 1BL6 1BL7 1BMK 1DI9 1IAN 1KV1 1KV2 1M7Q 1OUK 1OUY 1OVE 1OZ1 1R39 1R3C 1W7H 1W83 1W84 1WFC
Descriptor	MITOGEN-ACTIVATED PROTEIN KINASE 14, N-[(3Z)-5-TERT-BUTYL-2-PHENYL-1,2-DIHYDRO-3H-PYRAZOL-3-YLIDENE]-N'-(4-CHLOROPHENYL)UREA (3 entities in total)
Functional Keywords	kinase/inhibitor, kinase-inhibitor complex, p38, kinase, inhibitor complex
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cytoplasm : Q16539
Total number of polymer chains	1
Total formula weight	41712.06
Authors	Tickle, J.,Jhoti, H.,Cleasby, A.,Devine, L. (deposition date: 2004-09-16, release date: 2005-02-08, Last modification date: 2018-01-31)
Primary citation	Gill, A.,Frederickson, M.,Cleasby, A.,Woodhead, S.,Carr, M.,Woodhead, A.,Walker, M.,Congreve, M.,Devine, L.,Tisi, D.,O'Reilly, M.,Seavers, L.,Davis, D.,Curry, J.,Anthony, R.,Padova, A.,Murray, C.,Carr, R.,Jhoti, H. Identification of Novel P38Alpha Map Kinase Inhibitors Using Fragment-Based Lead Generation J.Med.Chem., 48:414-, 2005 Cited by PubMed: 15658855 DOI: 10.1021/JM049575N PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation