1UOM

The Structure of Estrogen Receptor in Complex with a Selective and Potent Tetrahydroisochiolin Ligand.

1UOM の概要

• エントリーDOI: 10.2210/pdb1uom/pdb
• 関連するPDBエントリー: 1A52 1AKF 1ERE 1ERR 1G50 1GWQ 1GWR 1HCP 1HCQ 1L2I 1QKT 1QKU 3ERD 3ERT
• 分子名称: ESTROGEN RECEPTOR, 2-PHENYL-1-[4-(2-PIPERIDIN-1-YL-ETHOXY)-PHENYL]-1,2,3,4-TETRAHYDRO-ISOQUINOLIN-6-OL (3 entities in total)
• 機能のキーワード: selective estrogen receptor modulators, serm, receptor, transcription regulation, dna-binding, nuclear protein, zinc-finger, steroid-binding, phosphorylation, polymorphism 3d-structure, alternative splicing
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Isoform 1: Nucleus. Isoform 3: Nucleus: P03372
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29400.59

構造登録者

Stark, W.,Bischoff, S.F.,Buhl, T.,Fournier, B.,Halleux, C.,Kallen, J.,Keller, H.,Renaud, J. (登録日: 2003-04-11, 公開日: 2003-07-03, 最終更新日: 2023-12-13)

• 主引用文献: Renaud, J.,Bischoff, S.F.,Buhl, T.,Floersheim, P.,Fournier, B.,Halleux, C.,Kallen, J.,Keller, H.,Schlaeppi, J.-M.,Stark, W.; Estrogen Receptor Modulators: Identification and Structure-Activity Relationships of Potent Eralpha-Selective Tetrahydroisoquinoline Ligands; J.Med.Chem., 46:2945-, 2003; PubMed: 12825935; DOI: 10.1021/JM030086H

実験手法

X-RAY DIFFRACTION (2.28 Å)