1TMM

Crystal structure of ternary complex of E.coli HPPK(W89A) with MGAMPCPP and 6-Hydroxymethylpterin

Summary for 1TMM

• Entry DOI: 10.2210/pdb1tmm/pdb
• Related: 1CBK 1DY3 1EQ0 1EQM 1EX8 1F9H 1F9Y 1G4C 1HKA 1HQ2 1IM6 1KBR 1Q0N 1RB0 1RTZ 1RU1 1RU2 1TMJ
• Descriptor: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, MAGNESIUM ION, CHLORIDE ION, ... (8 entities in total)
• Functional Keywords: pyrophosphokinase, pyrophosphoryl transfer, catalytic mechanism, folate, hppk, pterin, 6-hydroxymethyl-7, 8-dihydropterin, 6-hydroxymethylpterin, ternary complex, substrate specificity, product release, antimicrobial agent, drug design, transferase
• Biological source: Escherichia coli
• Total number of polymer chains: 2
• Total formula weight: 37747.79

Authors

Blaszczyk, J.,Li, Y.,Wu, Y.,Shi, G.,Ji, X.,Yan, H. (deposition date: 2004-06-10, release date: 2005-06-21, Last modification date: 2024-03-13)

• Primary citation: Li, Y.,Blaszczyk, J.,Wu, Y.,Shi, G.,Ji, X.,Yan, H.; Is the Critical Role of Loop 3 of Escherichia coli 6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase in Catalysis Due to Loop-3 Residues Arginine-84 and Tryptophan-89? Site-Directed Mutagenesis, Biochemical, and Crystallographic Studies.; Biochemistry, 44:8590-8599, 2005; PubMed: 15952765; DOI: 10.1021/bi0503495

Experimental method

X-RAY DIFFRACTION (1.25 Å)