Crystal structure of E.coli apo-HPPK(W89A) at 1.45 Angstrom resolution

Summary for 1TMJ

Related1HKA 1EQM 1EQ0 1Q0N 1EX8 1CBK 1DY3 1F9Y 1F9H 1G4C 1HQ2 1IM6 1KBR 1RU2 1RU1 1RTZ 1RB0 1TMM
Descriptor2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, MAGNESIUM ION, CHLORIDE ION, ... (4 entities in total)
Functional Keywordspyrophosphokinase, pyrophosphoryl transfer, folate, hppk, 6-hydroxymethylpterin, 6-hydroxymethyl-7, 8-dihydropterin, antimicrobial agent, drug design, point mutant, structural mutagenesis, transferase
Biological sourceEscherichia coli
Total number of polymer chains1
Total molecular weight17935.47
Blaszczyk, J.,Ji, X. (deposition date: 2004-06-10, release date: 2005-06-21, Last modification date: 2011-07-13)
Primary citation
Li, Y.,Blaszczyk, J.,Wu, Y.,Shi, G.,Ji, X.,Yan, H.
Is the Critical Role of Loop 3 of Escherichia coli 6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase in Catalysis Due to Loop-3 Residues Arginine-84 and Tryptophan-89? Site-Directed Mutagenesis, Biochemical, and Crystallographic Studies.
Biochemistry, 44:8590-8599, 2005
PubMed: 15952765 (PDB entries with the same primary citation)
DOI: 10.1021/bi0503495
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.168183.8%5.9%11.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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