1HKA

6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE

Summary for 1HKA

• Entry DOI: 10.2210/pdb1hka/pdb
• Descriptor: 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE (2 entities in total)
• Functional Keywords: pyrophosphoryl transfer, pyrophosphokinase, kinase, folate, 6-hydroxymethyl-7, 8-dihydropterin, transferase
• Biological source: Escherichia coli
• Total number of polymer chains: 1
• Total formula weight: 17966.53

Authors

Xiao, B.,Shi, G.,Chen, X.,Yan, H.,Ji, X. (deposition date: 1998-09-29, release date: 1999-06-08, Last modification date: 2023-08-30)

Primary citation

Xiao, B.,Shi, G.,Chen, X.,Yan, H.,Ji, X.
Crystal structure of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, a potential target for the development of novel antimicrobial agents.
Structure Fold.Des., 7:489-496, 1999

PubMed Abstract: Folate cofactors are essential for life. Mammals derive folates from their diet, whereas most microorganisms must synthesize folates de novo. Enzymes of the folate pathway therefore provide ideal targets for the development of antimicrobial agents. 6-Hydroxymethyl-7,8-dihydropterin pyrophosphokinase (HPPK) catalyzes the transfer of pyrophosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (HP), the first reaction in the folate biosynthetic pathway.

PubMed: 10378268
DOI: 10.1016/S0969-2126(99)80065-3

Experimental method

X-RAY DIFFRACTION (1.5 Å)