1TK5

T7 DNA polymerase binary complex with 8 oxo guanosine in the templating strand

Summary for 1TK5

Related1TK0 1T8E
Descriptor5'-D(*CP*GP*AP*AP*A*GP*CP*CP*AP*GP*TP*GP*CP*CP*AP*(DDG)P*TP*GP*CP*AP*A)-3', 5'-D(*CP*CP*CP*(8OG)P*CP*TP*GP*GP*CP*AP*CP*TP*GP*GP*CP*CP*GP*TP*CP*GP*TP*TP*TP*TP*CP*G)-3', DNA polymerase, ... (9 entities in total)
Functional Keywords8-oxoguanosine dna polymerase, transferase-electron transport-dna complex, transferase/electron transport/dna
Biological sourceEnterobacteria phage T7
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Total number of polymer chains4
Total molecular weight106130.58
Authors
Brieba, L.G.,Eichman, B.F.,Kokoska, R.J.,Doublie, S.,Kunkel, T.A.,Ellenberger, T. (deposition date: 2004-06-08, release date: 2004-08-31, Last modification date: 2018-01-31)
Primary citation
Brieba, L.G.,Eichman, B.F.,Kokoska, R.J.,Doublie, S.,Kunkel, T.A.,Ellenberger, T.
Structural basis for the dual coding potential of 8-oxoguanosine by a high-fidelity DNA polymerase.
Embo J., 23:3452-3461, 2004
PubMed: 15297882 (PDB entries with the same primary citation)
DOI: 10.1038/sj.emboj.7600354
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.2 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.241130.8%3.2%8.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report