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1T7P
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BU of 1t7p by Molmil
T7 DNA POLYMERASE COMPLEXED TO DNA PRIMER/TEMPLATE,A NUCLEOSIDE TRIPHOSPHATE, AND ITS PROCESSIVITY FACTOR THIOREDOXIN
Descriptor: 2'-3'-DIDEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA (5'-D(P*CP*CP*TP*TP*GP*GP*CP*AP*CP*TP*GP*GP*C)-3'), DNA (5'-D(P*GP*CP*CP*AP*GP*TP*GP*CP*CP*AP*2DA)-3'), ...
Authors:Doublie, S, Tabor, S, Long, A.M, Richardson, C.C, Ellenberger, T.
Deposit date:1997-09-24
Release date:1998-02-25
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 A resolution.
Nature, 391, 1998
1TDH
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BU of 1tdh by Molmil
Crystal structure of human endonuclease VIII-like 1 (NEIL1)
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, nei endonuclease VIII-like 1
Authors:Doublie, S, Bandaru, V, Bond, J.P, Wallace, S.S.
Deposit date:2004-05-22
Release date:2004-07-20
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The crystal structure of human endonuclease VIII-like 1 (NEIL1) reveals a zincless finger motif required for glycosylase activity.
Proc.Natl.Acad.Sci.USA, 101, 2004
6VJI
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BU of 6vji by Molmil
Structure of mammalian NEIL2 from Monodelphis domestica
Descriptor: Nei like DNA glycosylase 2, ZINC ION
Authors:Eckenroth, B.E, Doublie, S.
Deposit date:2020-01-16
Release date:2020-08-12
Last modified:2021-01-20
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:Unique Structural Features of Mammalian NEIL2 DNA Glycosylase Prime Its Activity for Diverse DNA Substrates and Environments.
Structure, 29, 2021
4MB7
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BU of 4mb7 by Molmil
Crystal Structure of a viral DNA glycosylase
Descriptor: Endonuclease 8-like L720, SULFATE ION, ZINC ION
Authors:Prakash, A, Eckenroth, B.E, Doublie, S.
Deposit date:2013-08-19
Release date:2013-10-30
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Structural investigation of a viral ortholog of human NEIL2/3 DNA glycosylases.
Dna Repair, 12, 2013
4M9J
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BU of 4m9j by Molmil
DNA Polymerase Beta E295K Soaked with dUMPNPP
Descriptor: 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, CHLORIDE ION, DNA Downstream Strand, ...
Authors:Eckenroth, B.E, Doublie, S.
Deposit date:2013-08-14
Release date:2013-10-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.038 Å)
Cite:The E295K Cancer Variant of Human Polymerase beta Favors the Mismatch Conformational Pathway during Nucleotide Selection.
J.Biol.Chem., 288, 2013
1Q79
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BU of 1q79 by Molmil
CRYSTAL STRUCTURE OF MAMMALIAN POLY(A) POLYMERASE
Descriptor: 3'-DEOXYADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, MANGANESE (II) ION, ...
Authors:Martin, G, Moglich, A, Keller, W, Doublie, S.
Deposit date:2003-08-16
Release date:2004-09-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Biochemical and structural insights into substrate binding and catalytic mechanism of mammalian poly(A) polymerase.
J.Mol.Biol., 341, 2004
3KD5
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BU of 3kd5 by Molmil
Closed ternary complex of an RB69 gp43 fingers domain mutant complexed with an acyclic GMP terminated primer template pair and phosphonoformic acid.
Descriptor: DNA (5'-D(*CP*GP*TP*CP*TP*TP*AP*TP*GP*AP*CP*AP*GP*CP*CP*GP*CP*G)-3'), DNA (5'-D(*GP*CP*GP*GP*CP*TP*GP*TP*CP*AP*TP*AP*AP*(4DG))-3'), DNA polymerase, ...
Authors:Zahn, K.E, Doublie, S.
Deposit date:2009-10-22
Release date:2011-04-13
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:Phosphonoformic acid inhibits viral replication by trapping the closed form of the DNA polymerase.
J.Biol.Chem., 286, 2011
3KD1
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BU of 3kd1 by Molmil
Closed binary complex of an RB69 gp43 fingers domain mutant complexed with an acyclic GMP terminated primer template pair.
Descriptor: DNA (5'-D(*CP*GP*TP*CP*TP*TP*AP*TP*GP*AP*CP*AP*GP*CP*CP*GP*CP*G)-3'), DNA (5'-D(*GP*CP*GP*GP*CP*TP*GP*TP*CP*AP*TP*AP*AP*(4DG))-3'), DNA polymerase, ...
Authors:Zahn, K.E, Doublie, S.
Deposit date:2009-10-22
Release date:2011-04-13
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.66 Å)
Cite:Phosphonoformic acid inhibits viral replication by trapping the closed form of the DNA polymerase.
J.Biol.Chem., 286, 2011
4X0P
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BU of 4x0p by Molmil
Ternary complex of human DNA polymerase theta C-terminal domain binding ddATP opposite a tetrahydrofuran AP site analog
Descriptor: 2',3'-dideoxyadenosine triphosphate, CALCIUM ION, DNA (5'-D(*CP*GP*TP*TP*GP*AP*AP*TP*GP*AP*CP*AP*GP*CP*CP*GP*CP*G)-3'), ...
Authors:Zahn, K.E, Doublie, S.
Deposit date:2014-11-21
Release date:2015-03-18
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.911 Å)
Cite:Human DNA polymerase theta grasps the primer terminus to mediate DNA repair.
Nat.Struct.Mol.Biol., 22, 2015
4X0Q
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BU of 4x0q by Molmil
Ternary complex of human DNA polymerase theta C-terminal domain binding ddGTP opposite dCMP
Descriptor: 2'-3'-DIDEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*CP*GP*TP*CP*CP*AP*AP*TP*GP*AP*CP*AP*G)-3'), DNA (5'-D(P*CP*TP*GP*TP*CP*AP*TP*TP*G)-3'), ...
Authors:Zahn, K.E, Doublie, S.
Deposit date:2014-11-22
Release date:2015-03-18
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:Human DNA polymerase theta grasps the primer terminus to mediate DNA repair.
Nat.Struct.Mol.Biol., 22, 2015
6MW4
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BU of 6mw4 by Molmil
Structure of pseudoprotease CspC from Clostridioides difficile
Descriptor: Putative germination-specific protease, SULFATE ION
Authors:Eckenroth, B.E, Doublie, S.
Deposit date:2018-10-29
Release date:2019-06-26
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:The CspC pseudoprotease regulates germination of Clostridioides difficile spores in response to multiple environmental signals.
Plos Genet., 15, 2019
8TH9
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BU of 8th9 by Molmil
Structure of mammalian NEIL2 from Monodelphis domestica in complex with THF-containing DNA
Descriptor: DIMETHYL SULFOXIDE, DNA (5'-D(*GP*CP*GP*TP*CP*CP*AP*(3DR)P*GP*TP*CP*TP*AP*C)-3'), DNA (5'-D(*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*G)-3'), ...
Authors:Eckenroth, B.E, Doublie, S.
Deposit date:2023-07-14
Release date:2023-11-01
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Structural and biochemical insights into NEIL2's preference for abasic sites.
Nucleic Acids Res., 51, 2023
8SYJ
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BU of 8syj by Molmil
Structure of apurinic/apyrimidinic DNA lyase TK0353 from Thermococcus kodakarensis (Iodide crystal form)
Descriptor: GLYCEROL, IODIDE ION, SULFATE ION, ...
Authors:Eckenroth, B.E, Gardner, A.F, Doublie, S.
Deposit date:2023-05-25
Release date:2023-12-06
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Thermococcus kodakarensis TK0353 is a novel AP lyase with a new fold.
J.Biol.Chem., 300, 2023
8GM6
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BU of 8gm6 by Molmil
Structure of apurinic/apyrimidinic DNA lyase TK0353 from Thermococcus kodakarensis (Selenomethionine)
Descriptor: GLYCEROL, SULFATE ION, TK0353
Authors:Eckenroth, B.E, Gardner, A.F, Doublie, S.
Deposit date:2023-03-24
Release date:2023-12-06
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Thermococcus kodakarensis TK0353 is a novel AP lyase with a new fold.
J.Biol.Chem., 300, 2023
8GM7
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BU of 8gm7 by Molmil
Structure of apurinic/apyrimidinic DNA Lyase TK0353 from Thermococcus kodakarensis (Native Crystal Form)
Descriptor: GLYCEROL, SULFATE ION, TK0353
Authors:Eckenroth, B.E, Gardner, A.F, Doublie, S.
Deposit date:2023-03-24
Release date:2023-12-06
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Thermococcus kodakarensis TK0353 is a novel AP lyase with a new fold.
J.Biol.Chem., 300, 2023
6BTE
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BU of 6bte by Molmil
DNA Polymerase Beta I260Q Binary Complex
Descriptor: CHLORIDE ION, DNA Downstream Strand, DNA Primer Strand, ...
Authors:Eckenroth, B.E, Doublie, S.
Deposit date:2017-12-06
Release date:2018-09-26
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:I260Q DNA polymerase beta highlights precatalytic conformational rearrangements critical for fidelity.
Nucleic Acids Res., 46, 2018
6BTF
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BU of 6btf by Molmil
DNA Polymerase Beta I260Q Ternary Complex
Descriptor: 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, DNA Downstream Strand, DNA Primer Strand, ...
Authors:Eckenroth, B.E, Doublie, S.
Deposit date:2017-12-06
Release date:2018-09-26
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:I260Q DNA polymerase beta highlights precatalytic conformational rearrangements critical for fidelity.
Nucleic Acids Res., 46, 2018
3I0X
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BU of 3i0x by Molmil
Crystal structure of Clostridium acetobutylicum 8-oxoguanine glycosylase/lyase in complex with dsDNA containing adenine opposite to 8-oxoG
Descriptor: 5'-D(*AP*TP*CP*CP*AP*(8OG)P*GP*TP*CP*TP*AP*CP*C)-3', 5'-D(*GP*GP*TP*AP*GP*AP*CP*AP*TP*GP*GP*A)-3', 8-oxoguanine-DNA-glycosylase, ...
Authors:Faucher, F, Doublie, S.
Deposit date:2009-06-25
Release date:2009-09-29
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis for the lack of opposite base specificity of Clostridium acetobutylicum 8-oxoguanine DNA glycosylase.
Dna Repair, 8, 2009
3I0W
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BU of 3i0w by Molmil
Crystal structure of Clostridium acetobutylicum 8-oxoguanine glycosylase/lyase in complex with dsDNA containing cytosine opposite to 8-oxoG
Descriptor: 1,2-ETHANEDIOL, 5'-D(*AP*TP*CP*CP*AP*(8OG)P*GP*TP*CP*TP*AP*CP*C)-3', 5'-D(*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*A)-3', ...
Authors:Faucher, F, Doublie, S.
Deposit date:2009-06-25
Release date:2009-09-29
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Structural basis for the lack of opposite base specificity of Clostridium acetobutylicum 8-oxoguanine DNA glycosylase.
Dna Repair, 8, 2009
7RAG
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BU of 7rag by Molmil
Structure of the CwlD amidase from Clostridioides difficile in complex with the GerS lipoprotein
Descriptor: 1,2-ETHANEDIOL, Germination-specific N-acetylmuramoyl-L-alanine amidase, Autolysin, ...
Authors:Eckenroth, B.E, Doublie, S.
Deposit date:2021-07-01
Release date:2021-09-08
Last modified:2021-10-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A lipoprotein allosterically activates the CwlD amidase during Clostridioides difficile spore formation.
Plos Genet., 17, 2021
7RDS
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BU of 7rds by Molmil
Structure of human NTHL1
Descriptor: IRON/SULFUR CLUSTER, Isoform 3 of Endonuclease III-like protein 1
Authors:Carroll, B.L, Zahn, K.E, Doublie, S.
Deposit date:2021-07-11
Release date:2021-12-29
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Caught in motion: human NTHL1 undergoes interdomain rearrangement necessary for catalysis.
Nucleic Acids Res., 49, 2021
7RDT
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BU of 7rdt by Molmil
Structure of human NTHL1 - linker 1 chimera
Descriptor: IRON/SULFUR CLUSTER, Isoform 3 of Endonuclease III-like protein 1
Authors:Carroll, B.L, Doublie, S.
Deposit date:2021-07-11
Release date:2021-12-29
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Caught in motion: human NTHL1 undergoes interdomain rearrangement necessary for catalysis.
Nucleic Acids Res., 49, 2021
3RMA
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BU of 3rma by Molmil
Crystal Structure of a replicative DNA polymerase bound to DNA containing Thymine Glycol
Descriptor: DNA (5'-D(*CP*GP*AP*(CTG)*GP*AP*AP*TP*GP*AP*CP*AP*GP*CP*CP*GP*CP*G)-3'), DNA (5'-D(*GP*CP*GP*GP*CP*TP*GP*TP*CP*AP*TP*TP*CP*A)-3'), DNA polymerase
Authors:Aller, P, Duclos, S, Wallace, S.S, Doublie, S.
Deposit date:2011-04-20
Release date:2011-08-10
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.84 Å)
Cite:A crystallographic study of the role of sequence context in thymine glycol bypass by a replicative DNA polymerase serendipitously sheds light on the exonuclease complex.
J.Mol.Biol., 412, 2011
3RMC
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BU of 3rmc by Molmil
Crystal Structure of a replicative DNA polymerase bound to DNA containing Thymine Glycol
Descriptor: DNA (5'-D(*CP*GP*TP*(CTG)P*GP*AP*AP*TP*GP*AP*CP*AP*GP*CP*CP*GP*CP*G)-3'), DNA (5'-D(*GP*CP*GP*GP*CP*TP*GP*TP*CP*AP*TP*TP*CP*A)-3'), DNA polymerase
Authors:Aller, P, Duclos, S, Wallace, S.S, Doublie, S.
Deposit date:2011-04-20
Release date:2011-08-10
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:A crystallographic study of the role of sequence context in thymine glycol bypass by a replicative DNA polymerase serendipitously sheds light on the exonuclease complex.
J.Mol.Biol., 412, 2011
3RMB
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BU of 3rmb by Molmil
Crystal Structure of a replicative DNA polymerase bound to DNA containing Thymine Glycol
Descriptor: DNA (5'-D(*CP*GP*CP*(CTG)P*GP*AP*AP*TP*GP*AP*CP*AP*GP*CP*CP*GP*CP*G)-3'), DNA (5'-D(*GP*CP*GP*GP*CP*TP*GP*TP*CP*AP*TP*TP*CP*A)-3'), DNA polymerase, ...
Authors:Aller, P, Duclos, S, Wallace, S.S, Doublie, S.
Deposit date:2011-04-20
Release date:2011-08-10
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:A crystallographic study of the role of sequence context in thymine glycol bypass by a replicative DNA polymerase serendipitously sheds light on the exonuclease complex.
J.Mol.Biol., 412, 2011

 

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