3KD5
Closed ternary complex of an RB69 gp43 fingers domain mutant complexed with an acyclic GMP terminated primer template pair and phosphonoformic acid.
Summary for 3KD5
Entry DOI | 10.2210/pdb3kd5/pdb |
Related | 3KD1 |
Descriptor | DNA (5'-D(*CP*GP*TP*CP*TP*TP*AP*TP*GP*AP*CP*AP*GP*CP*CP*GP*CP*G)-3'), DNA (5'-D(*GP*CP*GP*GP*CP*TP*GP*TP*CP*AP*TP*AP*AP*(4DG))-3'), DNA polymerase, ... (6 entities in total) |
Functional Keywords | polymerase, gp43, human cytomegalovirus, hcmv, acyclic guanosine, acyclovir, phosphonoformic acid, foscarnet, foscavir, antiviral, dna replication, dna-binding, dna-directed dna polymerase, exonuclease, hydrolase, nuclease, nucleotidyltransferase, transferase, transferase-dna complex, transferase/dna |
Biological source | Enterobacteria phage RB69 (Bacteriophage RB69) More |
Total number of polymer chains | 3 |
Total formula weight | 115776.61 |
Authors | Zahn, K.E.,Doublie, S. (deposition date: 2009-10-22, release date: 2011-04-13, Last modification date: 2023-09-06) |
Primary citation | Zahn, K.E.,Tchesnokov, E.P.,Gotte, M.,Doublie, S. Phosphonoformic acid inhibits viral replication by trapping the closed form of the DNA polymerase. J.Biol.Chem., 286:25246-25255, 2011 Cited by PubMed: 21566148DOI: 10.1074/jbc.M111.248864 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.69 Å) |
Structure validation
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