1OKX
Binding Structure of Elastase Inhibitor Scyptolin A
Summary for 1OKX
| Entry DOI | 10.2210/pdb1okx/pdb |
| Related | 1B0E 1BMA 1BTU 1C1M 1E34 1E35 1E36 1E37 1E38 1EAI 1EAS 1EAT 1EAU 1ELA 1ELB 1ELC 1ELD 1ELE 1ELF 1ELG 1ESA 1ESB 1EST 1FLE 1FZZ 1GVK 1GWA 1H9L 1HAX 1HAY 1HAZ 1HB0 1HV7 1INC 1JIM 1L0Z 1L1G 1LKA 1LKB 1LVY 1MCV 1MMJ 1NES 1QGF 1QIX 1QNJ 1QR3 2EST 3EST 4EST 5EST 6EST 7EST 8EST 9EST |
| Related PRD ID | PRD_000187 |
| Descriptor | ELASTASE 1, SCYPTOLIN A (3 entities in total) |
| Functional Keywords | protease, elastase, inhibitor, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | SUS SCROFA (PIG) More |
| Total number of polymer chains | 4 |
| Total formula weight | 53827.18 |
| Authors | Matern, U.,Schleberger, C.,Jelakovic, S.,Weckesser, J.,Schulz, G.E. (deposition date: 2003-07-31, release date: 2003-10-24, Last modification date: 2023-12-13) |
| Primary citation | Matern, U.,Schleberger, C.,Jelakovic, S.,Weckesser, J.,Schulz, G.E. Binding Structure of Elastase Inhibitor Scyptolin A Chem.Biol., 10:997-, 2003 Cited by PubMed Abstract: Natural bioactive compounds are of general interest to pharmaceutical research because they may be used as leads in drug development campaigns. Among them, scyptolin A and B from Scytonema hofmanni PCC 7110 are known to inhibit porcine pancreatic elastase, which in turn resembles the attractive drug target neutrophil elastase. The crystal structure of scyptolin A as bound to pancreatic elastase was solved at 2.8 A resolution. The inhibitor occupies the most prominent subsites S1 through S4 of the elastase and prevents a hydrolytic attack by covering the active center with its rigid ring structure. The observed binding structure may help to design potent elastase inhibitors. PubMed: 14583266DOI: 10.1016/J.CHEMBIOL.2003.10.001 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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