1EAU

NONPEPTIDIC INHIBITORS OF HUMAN LEUKOCYTE ELASTASE. 6. DESIGN OF A POTENT, INTRATRACHEALLY ACTIVE, PYRIDONE-BASED TRIFLUOROMETHYL KETONE

Summary for 1EAU

Entry DOI	10.2210/pdb1eau/pdb
Descriptor	PORCINE PANCREATIC ELASTASE, SODIUM ION, SULFATE ION, ... (5 entities in total)
Functional Keywords	hydrolase (serine protease)
Biological source	Sus scrofa (pig)
Cellular location	Secreted: P00772
Total number of polymer chains	1
Total formula weight	26587.67
Authors	Ceccarelli, C. (deposition date: 1994-11-22, release date: 1995-02-07, Last modification date: 2011-07-13)
Primary citation	Bernstein, P.R.,Gomes, B.C.,Kosmider, B.J.,Vacek, E.P.,Williams, J.C. Nonpeptidic inhibitors of human leukocyte elastase. 6. Design of a potent, intratracheally active, pyridone-based trifluoromethyl ketone. J.Med.Chem., 38:212-215, 1995 Cited by PubMed: 7837235 DOI: 10.1021/jm00001a028 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation