1EA5

NATIVE ACETYLCHOLINESTERASE (E.C. 3.1.1.7) FROM TORPEDO CALIFORNICA at 1.8A resolution

Summary for 1EA5

• Entry DOI: 10.2210/pdb1ea5/pdb
• Related: 1AMN 1AX9 1CFJ 1DX6 1E3Q 1E66 1EEA 1EVE 1FSS 1OCE 1QID 1QIE 1QIF 1QIG 1QIH 1QII 1QIJ 1QIK 1QIM 1QTI 1SOM 1VOT 1VXO 1VXR 2ACE 2ACK 2DFP 3ACE
• Descriptor: ACETYLCHOLINESTERASE, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
• Functional Keywords: hydrolase, serine hydrolase, neurotransmitter cleavage, catalytic triad, alpha/beta hydrolase
• Biological source: TORPEDO CALIFORNICA (PACIFIC ELECTRIC RAY)
• Total number of polymer chains: 1
• Total formula weight: 61178.93

Authors

Harel, M.,Weik, M.,Silman, I.,Sussman, J.L. (deposition date: 2000-11-06, release date: 2000-11-08, Last modification date: 2023-12-13)

• Primary citation: Dvir, H.,Jiang, H.L.,Wong, D.M.,Harel, M.,Chetrit, M.,He, X.C.,Jin, G.Y.,Yu, G.L.,Tang, X.C.,Silman, I.,Bai, D.L.,Sussman, J.L.; X-Ray Structures of Torpedo Californica Acetylcholinesterase Complexed with (+)-Huperzine a and (-)-Huperzine B: Structural Evidence for an Active Site Rearrangement; Biochemistry, 41:10810-, 2002; PubMed: 12196020; DOI: 10.1021/BI020151+

Experimental method

X-RAY DIFFRACTION (1.8 Å)