1C1C
CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH TNK-6123
Summary for 1C1C
Entry DOI | 10.2210/pdb1c1c/pdb |
Related | 1C0T 1C0U 1C1B 1KLM 1REV 1RT1 1RT2 1RT3 1RT4 1RT5 1RT6 1RT7 1RTH 1RTI 1RTJ 1RTV 1VRU |
Descriptor | HIV-1 REVERSE TRANSCRIPTASE (A-CHAIN), HIV-1 REVERSE TRANSCRIPTASE (B-CHAIN), 6-(cyclohexylsulfanyl)-1-(ethoxymethyl)-5-(1-methylethyl)pyrimidine-2,4(1H,3H)-dione, ... (4 entities in total) |
Functional Keywords | hiv-1 reverse transcriptase, aids, non-nucleoside inhibitor, drug design, transferase |
Biological source | Human immunodeficiency virus 1 More |
Cellular location | Matrix protein p17: Virion . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585 P04585 |
Total number of polymer chains | 2 |
Total formula weight | 116320.45 |
Authors | Hopkins, A.L.,Ren, J.,Tanaka, H.,Baba, M.,Okamato, M.,Stuart, D.I.,Stammers, D.K. (deposition date: 1999-07-21, release date: 2000-07-21, Last modification date: 2014-11-12) |
Primary citation | Hopkins, A.L.,Ren, J.,Tanaka, H.,Baba, M.,Okamato, M.,Stuart, D.I.,Stammers, D.K. Design of MKC-442 (emivirine) analogues with improved activity against drug-resistant HIV mutants. J.Med.Chem., 42:4500-4505, 1999 Cited by PubMed: 10579814DOI: 10.1021/jm990192c PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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